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OPEN

System innovation experimentation for Industry 5.0 (IA)

Last Updated: 8/19/2025Deadline: 22 September 2025€45.0M Available

Quick Facts

Programme:Horizon Europe
Call ID:HORIZON-CL4-INDUSTRY-2025-01-HUMAN-65
Deadline:22 September 2025
Max funding:€45.0M
Status:
open
Time left:2 months

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💰 Funding Details

System innovation experimentation for Industry 5.0 (IA)


Essential Facts

* Call Identifier: HORIZON-CL4-INDUSTRY-2025-01-HUMAN-65

* Programme: Horizon Europe – Cluster 4 *Digital, Industry & Space*

* Type of Action: Innovation Action (IA) – Lump-Sum Grant

* Max. EU Contribution: €45 million per project

* Submission Model: Single-stage

* Opening Date: 22 May 2025

* Deadline: 23 Sept 2025 – 17:00 Brussels time

* Indicative Project Duration: ~36 months


Purpose of the Call

The call finances large-scale system innovation experiments that demonstrate how Industry 5.0 principles—human-centricity, sustainability and resilience—can be embedded in regional/local industrial ecosystems. Projects must:

1. Prototype and validate incentive schemes that trigger long-term Industry 5.0 transformations.

2. Deploy learning-organisation models that close skills gaps and attract talent.

3. Show measurable competitiveness gains and increased resilience linked to the twin transition (green & digital).

4. Generate policy evidence and exploitation pathways that enable replication across European Regional Innovation Valleys and beyond.


Eligible Activities

* Systemic experimentation sandboxes involving quadruple/quintuple-helix stakeholders.

* Skills foresight & curricula co-creation aligned with identified technological and organisational innovations.

* Digital/AI-enabled decision-support tools for value-chain orchestration and skills anticipation.

* Peer-learning & leadership catalysing actions that scale learning-ecosystem concepts.

* Financial support to third parties (up to €60 000 each) to amplify experimentation.


Expected Impact

* Proven incentive models increasing Industry 5.0 uptake in at least three distinct industrial ecosystems.

* Documented organisational learning capacity gains (KPIs: training hours, retention, new skills profiles).

* Tangible competitiveness indicators (e.g. productivity, energy reduction, time-to-market) benchmarked against the pre-project baseline.

* Policy recommendations and open assets feeding the *Community of Practice on Industry 5.0* and future EU initiatives.


Personalizing...

📊 At a Glance

€45.0M
Max funding
22 September 2025
Deadline
2 months
Time remaining
Eligible Countries
EU Member States, Associated Countries

🇪🇺 Strategic Advantages

EU-Wide Advantages & Strategic Opportunities for "System innovation experimentation for Industry 5.0 (IA)"


Executive Snapshot

This Horizon Innovation Action offers one of the most powerful EU-level springboards for piloting, validating and scaling Industry 5.0 methods across multiple industrial ecosystems. Operating at European rather than national scale unlocks larger markets, richer knowledge flows, harmonised regulation and synergistic public–private finance—creating a multiplier effect that no single Member State can replicate on its own.


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1. Alignment With Flagship EU Policies

European Green Deal & Fit-for-55 – projects accelerating clean-tech uptake or circular value chains directly contribute to climate-neutrality targets.

Digital Decade/Path to the Digital Decade 2030 – focus on human-centric digitalisation meets the EU’s twin-transition ambitions.

Industrial Strategy & SME Strategy – systemic transformation at regional level strengthens the resilience of 14 identified industrial ecosystems.

Pact for Skills & European Year of Skills – reskilling/up-skilling activities feed into EU-wide large-scale skills partnerships.

New European Bauhaus & Regional Innovation Valleys – aesthetic, sustainable and inclusive innovation concepts can be integrated, unlocking access to complementary calls.


> Strategic value: Policy coherence increases evaluation scores, eases future regulatory approvals and paves the way for structural fund top-ups after the project.


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2. Single Market Access: 450+ Million Consumers

• Pilots validated under harmonised EU rules can be commercialised in 27 countries without additional technical adaptation, slashing time-to-market.

• Early engagement with standards bodies (CEN, CENELEC, ETSI) during the project supports “design-for-compliance” and future CE-marking.

• Consortia may test new incentive schemes in diversified socio-economic contexts (e.g. Nordics vs. Southern Europe) and collect robust, generalisable evidence—a clear asset when pitching to private investors.


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3. Cross-Border Collaboration & Knowledge Exchange

Mandatory transdisciplinary consortia incentivise partnerships between leading RTOs (Fraunhofer, TNO, CEA, VTT, etc.), top universities, industrial leaders and regional authorities.

• The call explicitly asks for SSH integration—a strong opportunity to tap into EU-wide social-innovation expertise (e.g. Danish Design Centre, Spanish cooperative clusters).

• Access to EU platforms such as Industry 5.0 Community of Practice, EIT Manufacturing Co-Location Centres and Digital Innovation Hubs (EDIHs) accelerates dissemination and peer learning.


Outcome: faster iteration cycles, shared sandbox infrastructures, and lower duplication of effort across Member States.


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4. Regulatory Harmonisation & Standards Leadership

• The IA can act as a living laboratory for forthcoming EU regulations (AI Act, Machinery Regulation, Data Act) and feed empirical evidence back to Brussels.

• Early movers gain a seat at standardisation tables, allowing partners to shape de-facto pan-European standards for human-centric, eco-designed manufacturing systems.


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5. Pan-European Innovation Ecosystem Leverage

Complementary programmes: Made-in-Europe & Process4Planet partnerships, EIT KICs, Interregional Innovation Investments (I3), Erasmus+ Alliances.

Clusters & networks: Vanguard Initiative, ERRIN, Enterprise Europe Network—facilitate matchmaking with SMEs and investors across borders.

Testing zones: RegHub, European Test Beds Catalogue and EDIHs provide physical & digital sandboxes already co-funded by the EU.


Benefits: reduced CAPEX for pilots, access to unique expertise (e.g. photonics in NL, robotics in IT, bio-based processes in FI).


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6. Funding Synergies & Financial Engineering

Cascade funding (≤ €60 000/3rd party) enables rapid onboarding of SMEs and start-ups in multiple countries, spreading risk and widening impact.

• Alignment with Cohesion Policy 2021-2027 Smart Specialisation priorities unlocks ERDF/Just Transition co-funding for post-project scale-up.

• Results create pipelines for InvestEU and the Innovation Fund (e.g. large-scale green manufacturing lines) or EIB blended finance.


Financial advantage: EU ecosystem reduces capital fragmentation, offering blended, phased financing from TRL 5 to TRL 9.


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7. Scale, Visibility & Replication Potential

• Deliverables (methodology toolkit, AI-enabled decision tools, incentive models) are expected to be openly licensed or easily replicable under the Horizon principle of open science—facilitating EU-wide diffusion.

• Horizon branding provides credibility when approaching additional regions for replication (e.g. via the "Plug-in" mechanism of Regional Innovation Valleys).

• The wide geographical coverage expected by evaluators guarantees datasets robust enough for policy uptake at EU level (DG RTD, DG GROW, DG EMPL).


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8. Talent Attraction & Skills Agenda

• Cross-border pilot sites become magnet projects for high-skill workers, building on intra-EU mobility schemes (EURES, Erasmus+ Traineeships).

• Alignment with the Pact for Skills allows consortia to integrate micro-credentials that are recognised EU-wide, making reskilling programmes portable across regions.


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9. ESG & Sustainable Finance Alignment

• Industry 5.0 KPIs (human-centricity, sustainability, resilience) map directly onto EU Taxonomy objectives—facilitating access to sustainable investment capital after project end.

• Compliance with EU CSR directives enhances corporate reputation and investor relations across the single market.


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10. Risk Mitigation Through the Lump-Sum Model

• Horizon lump-sum grants remove the administrative burden of actual-cost reporting, making multi-country financial management simpler and more predictable.

• Uniform EU rules on IP (DESCA 2020 model, if adopted) streamline exploitation agreements across legal jurisdictions.


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11. Stakeholder-Specific Opportunity Map

Large enterprises – steer EU standards; pilot agile, human-centric factories in multiple Member States.

SMEs & Start-ups – receive cascade funding and immediate access to cross-border customer bases and testbeds.

Regional authorities – showcase smart-specialisation strategies, attract FDI and talent, and secure ERDF top-ups.

Research organisations – obtain real-life data and new research questions for Horizon Europe Pillar I opportunities.

Civil society & workers – participate in co-creation workshops, ensuring social acceptance and inclusive outcomes.


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12. Practical Next Steps to Maximise EU-Level Advantages

1. Gap map EU programmes (ERDF, ESF+, I3, EIT, Eureka) against your work plan to create a multi-annual financing roadmap.

2. Secure letters of intent from at least three Regional Innovation Valleys to demonstrate replication capacity.

3. Engage CEN/CENELEC workshop agreements early to shape pre-standards.

4. Bundle SSH, technological and policy expertise from a minimum of 8 Member States to strengthen the systemic approach demanded by the call.

5. Design an open cascade-funding call calendar aligned with national cluster events (Hannover Messe, Global Industrie, etc.) for maximum SME uptake.


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Conclusion

Leveraging the single market, harmonised regulations and a dense innovation ecosystem, this Horizon IA provides an unprecedented EU-wide platform to de-risk, validate and mainstream Industry 5.0 approaches. By aligning with flagship EU strategies and tapping into complementary funding streams, consortia can achieve transformative impact that scales well beyond individual regions—accelerating Europe’s transition toward a human-centric, sustainable and globally competitive industrial future.

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