Leveraging multimodal data to advance Generative Artificial Intelligence applicability in biomedical research (GenAI4EU)
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GenAI4EU – Funding Overview
Purpose of the Call
The call HORIZON-HLTH-2025-01-TOOL-03 finances research and innovation actions that design, validate and openly disseminate trustworthy Generative AI solutions able to exploit large-scale multimodal biomedical data for predictive and personalised medicine.
Key Funding Parameters
- Type of Action: Horizon Europe Research and Innovation Action (HORIZON-RIA)
- Maximum EU contribution per project: up to €80 000 000 (100 % of eligible direct costs + 25 % flat-rate indirect costs)
- Project length: typically 48–60 months
- Submission model: single stage – deadline 16 September 2025 (17:00 Brussels time)
- Minimum consortium requirement: at least three independent legal entities from three different EU Member States or Associated Countries, each established in a different country and at least one of them established in an EU Member State
What the Grant Funds
1. Development or re-purposing of Generative AI models using complex, multimodal biomedical data (e.g. images, omics, EHR, unstructured text)
2. High-performance computing resources, data engineering, federated learning, synthetic data generation
3. Proof-of-concept validation in at least two distinct medical fields relevant to predictive and personalised medicine
4. Methodologies and tools for continual evaluation: performance, explainability, robustness, bias mitigation, alignment with ethical principles, ELSI analysis, GDPR compliance
5. User-centred activities: co-design with researchers/clinicians, usability testing, training materials, capacity-building programmes
6. Dissemination, exploitation, open-source release, FAIR data stewardship, Intellectual Property management
7. Networking and joint activities with other EU-funded projects (budget line expected)
8. Project management, governance, ethics, SSH integration and gender action plans
Costs **not** in scope
- Creation or large-scale expansion of health data or AI infrastructures/platforms
- Commercial clinical implementation activities beyond PoC/research
Eligibility Snapshot
- Who may coordinate/participate: universities, research institutes, hospitals, SMEs and industry (incl. AI start-ups), HPC centres, patient organisations, social sciences & humanities (SSH) entities, EU agencies (e.g. JRC)
- Geography: EU-27 & Horizon-Europe-Associated Countries; US entities are exceptionally eligible for funding; entities deemed high-risk 5G suppliers are excluded when relevant
- Special participation expectations:
• Inclusion of EU AI developers/start-ups
• Meaningful SSH involvement
• Engagement of potential end-users (researchers/clinicians)
• Open-science mindset and, where feasible, open-source licensing
Compliance & Policy Anchors
- GDPR and EU AI Act preparedness
- FAIR data principles and EOSC recommendations
- Ethics Guidelines for Trustworthy AI & ERA Forum guidelines on Generative AI
- Synergies with EHDS, GDI, Cancer Image Europe, EOSC, AI Factories, Partnerships (e.g. Rare Diseases, Cancer Mission)
Evaluation Mechanics
Criterion | Weight | Threshold
--- | --- | ---
Excellence | 1/3 | 4/5
Impact | 1/3 | 4/5
Quality & Efficiency of Implementation | 1/3 | 4/5
Cumulative minimum: 12/15
High-level Timeline
- Call opens: 22 May 2025
- Deadline: 16 Sep 2025
- Evaluation results: Dec 2025
- Grant agreement signature: Apr–Jun 2026
- Project start: Q3 2026
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